Objective: Our study aimed to examine the inflammatory status, which is meticulously regulated during pregnancy, and the variations between trimesters and retrospectively assess the differences among trimesters by analyzing the maternal hematological-inflammatory-biomarker-data of healthy pregnant women.
Materials and Methods: The study population consisted of 42 uncomplicated pregnancies who were within 14 gestational weeks and applied for routine pregnancy follow-up at Karaman Training and Research Hospital between 01.08.2023 and 01.05.2024. Jamovi 2.6 was used for statistical analyses applying to the department.
Results: The study comprised 42 pregnant women with an average age of 26.5 years (range: 23.0-30.0), and their average body mass index was 27.9 (range: 25.9-33.1). In the second trimester, MCV, RDW, and PDW exhibit a statistically significant increase (p<0.001 for all). SIRI, AISI, NLR, and MLR were statistically substantially elevated in the second trimester compared to the other trimesters (p=0.001, p=0.042, p=0.002, p=0.015, respectively). No statistically significant difference was detected between SII and the trimesters. Upon examining the correlation of hematological inflammatory indices with advancing gestational age and among themselves, it was found that SIRI, NLR, and MLR exhibited a weak positive correlation with gestational weeks (Spearman’s; rho=0.228, p=0.01; 0.191, p=0.032; 0.205, p=0.022, respectively).
Conclusion: We have determined the standard range of inflammatory indicators in healthy pregnant individuals across each trimester.