This article aims to determine the role of oxidative stress (OS) in important eye diseases and draw attention to its importance in eye health. Oxidative stress is an important pathomechanism in many ocular degenerative diseases. This article offers an overview and recent updates on research regarding the mechanism and treatment of eye diseases caused by an imbalance between oxidants and antioxidants. We examine oxidative damage, such as lipid peroxidation, DNA damage, and apoptosis, that occurs in various parts of the eye, including the cornea, anterior chamber, lens, retina, and optic nerve. In particular, we evaluate the association of dry eye, pterygium, keratoconus, glaucoma, cataract, age-related macular degeneration, and diabetic retinopathy with OS. We believe that it will increase clinician awareness as it is a guiding review of natural antioxidant treatments for ocular diseases associated with oxidative stress.